Hypoglycaemia after Moxidectin (ProHeart 6) in dogs

The FDA has received 139 reports of hypoglycaemia in dogs after Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

139Reports

55%Marked serious

4.3%Recovered

45%Died or euthanised

1 daysTypical onset

How soon it started

Same day

37 43%

1–2 days

19 22%

3–7 days

14 16%

1–4 weeks

7 8.0%

Over a month

10 11%

How the animals did

Recovered

6 4.3%

Still unwell when reported

42 30%

Died

40 29%

Euthanised

23 17%

Not known

28 20%

Problems reported at the same time

81 58%

69 50%

68 49%

67 48%

63 45%

43 31%

37 27%

37 27%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hypoglycaemia in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoglycaemia with similar medicines

Hypoglycaemia after Ivermectin + Pyrantel (Heartgard Plus) 93 reports · 0.1% of its reports
Hypoglycaemia after Milbemycin Oxime + Spinosad (Trifexis) 147 reports · 0.1% of its reports
Hypoglycaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 32 reports · 0.1% of its reports
Hypoglycaemia after Milbemycin Oxime (Interceptor) 52 reports · 0.2% of its reports
Hypoglycaemia after Selamectin (Revolution) 92 reports · 0.3% of its reports
Hypoglycaemia after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hypoglycaemia