Falling after Selamectin (Revolution) in dogs

The FDA has received 36 reports of falling in dogs after Selamectin. That is 0.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

36Reports

58%Marked serious

39%Recovered

8.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

13 42%

1–2 days

7 23%

3–7 days

1 3.2%

1–4 weeks

5 16%

Over a month

5 16%

How the animals did

Recovered

13 36%

Recovered with lasting effects

1 2.8%

Still unwell when reported

15 42%

Died

2 5.6%

Euthanised

1 2.8%

Not known

4 11%

Problems reported at the same time

13 36%

12 33%

11 31%

11 31%

10 28%

8 22%

7 19%

6 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause falling in dogs?: 36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Falling with similar medicines

Falling after Ivermectin + Pyrantel (Heartgard Plus) 312 reports · 0.2% of its reports
Falling after Milbemycin Oxime + Spinosad (Trifexis) 393 reports · 0.3% of its reports
Falling after Moxidectin (ProHeart 6) 117 reports · 0.2% of its reports
Falling after Milbemycin Oxime + Praziquantel (Interceptor Plus) 121 reports · 0.4% of its reports
Falling after Milbemycin Oxime (Interceptor) 40 reports · 0.1% of its reports
Falling after Ivermectin (Heartgard) 75 reports · 0.6% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with falling