Elevated lipase after Selamectin (Revolution) in dogs

27 reports to the FDA describe elevated lipase in dogs given Selamectin. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

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How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause elevated lipase in dogs?

27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

• Elevated lipase after Ivermectin + Pyrantel (Heartgard Plus) 107 reports · 0.1% of its reports
• Elevated lipase after Milbemycin Oxime + Spinosad (Trifexis) 128 reports · 0.1% of its reports
• Elevated lipase after Moxidectin (ProHeart 6) 108 reports · 0.2% of its reports
• Elevated lipase after Milbemycin Oxime + Praziquantel (Interceptor Plus) 38 reports · 0.1% of its reports
• Elevated lipase after Milbemycin Oxime (Interceptor) 48 reports · 0.2% of its reports
• Elevated lipase after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with elevated lipase