Elevated lipase after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

The FDA has received 38 reports of elevated lipase in dogs after Milbemycin Oxime + Praziquantel. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

38Reports

63%Marked serious

18%Recovered

21%Died or euthanised

40 daysTypical onset

How soon it started

Same day

1 4.8%

1–2 days

3 14%

3–7 days

1 4.8%

1–4 weeks

2 9.5%

Over a month

14 67%

How the animals did

Recovered

7 18%

Still unwell when reported

13 34%

Died

2 5.3%

Euthanised

6 16%

Not known

10 26%

Problems reported at the same time

19 50%

16 42%

16 42%

13 34%

13 34%

12 32%

12 32%

10 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause elevated lipase in dogs?: 38 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 40 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Ivermectin + Pyrantel (Heartgard Plus) 107 reports · 0.1% of its reports
Elevated lipase after Milbemycin Oxime + Spinosad (Trifexis) 128 reports · 0.1% of its reports
Elevated lipase after Moxidectin (ProHeart 6) 108 reports · 0.2% of its reports
Elevated lipase after Milbemycin Oxime (Interceptor) 48 reports · 0.2% of its reports
Elevated lipase after Selamectin (Revolution) 27 reports · 0.1% of its reports
Elevated lipase after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with elevated lipase