Elevated lipase after Moxidectin (ProHeart 6) in dogs

108 reports to the FDA describe elevated lipase in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

108Reports

40%Marked serious

10%Recovered

26%Died or euthanised

1 daysTypical onset

How soon it started

Same day

22 46%

1–2 days

16 33%

3–7 days

2 4.2%

1–4 weeks

4 8.3%

Over a month

4 8.3%

How the animals did

Recovered

11 10%

Still unwell when reported

32 30%

Died

21 19%

Euthanised

7 6.5%

Not known

37 34%

Problems reported at the same time

60 56%

57 53%

48 44%

48 44%

43 40%

39 36%

33 31%

28 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause elevated lipase in dogs?: 108 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Ivermectin + Pyrantel (Heartgard Plus) 107 reports · 0.1% of its reports
Elevated lipase after Milbemycin Oxime + Spinosad (Trifexis) 128 reports · 0.1% of its reports
Elevated lipase after Milbemycin Oxime + Praziquantel (Interceptor Plus) 38 reports · 0.1% of its reports
Elevated lipase after Milbemycin Oxime (Interceptor) 48 reports · 0.2% of its reports
Elevated lipase after Selamectin (Revolution) 27 reports · 0.1% of its reports
Elevated lipase after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with elevated lipase