Liver problems after Same And Silybin in dogs

The FDA has received 21 reports of liver problems in dogs after Same And Silybin. That is 42% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports
81%Marked serious
0.0%Recovered
29%Died or euthanised
39 daysTypical onset
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How soon it started

Same day
1 7.1%
1–2 days
0 0.0%
3–7 days
2 14%
1–4 weeks
0 0.0%
Over a month
11 79%

How the animals did

Still unwell when reported
7 33%
Died
2 9.5%
Euthanised
4 19%
Not known
8 38%

Problems reported at the same time

Lethargy
8 38%
Kidney problems
8 38%
Abnormal ultrasound finding
7 33%
Death
6 29%
Vomiting
6 29%
Diarrhea
6 29%
Elevated gamma-glutamyl transferase (ggt)
5 24%
Loss of appetite
5 24%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
1
8–11 years
7
12+ years
11

About this medicine

Type: medicine.

Questions owners ask

Can Same And Silybin cause liver problems in dogs?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 39 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Same And Silybin in dogs · Medicines most reported with liver problems