Weight gain after Pyrantel + Sarolaner (Simparica Trio) in dogs

31 reports to the FDA describe weight gain in dogs given Pyrantel + Sarolaner. That is 0.1% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

31Reports
58%Marked serious
3.2%Recovered
6.5%Died or euthanised
136 daysTypical onset
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How soon it started

Same day
2 9.5%
1–2 days
2 9.5%
3–7 days
0 0.0%
1–4 weeks
1 4.8%
Over a month
16 76%

How the animals did

Recovered
1 3.2%
Still unwell when reported
14 45%
Died
1 3.2%
Euthanised
1 3.2%
Not known
14 45%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
17
4–7 years
7
8–11 years
3
12+ years
0

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause weight gain in dogs?
31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 136 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight gain with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with weight gain