Stomach upset after Pyrantel + Sarolaner (Simparica Trio) in dogs

100 reports to the FDA describe stomach upset in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

100Reports

17%Marked serious

33%Recovered

2.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

74 79%

1–2 days

9 9.6%

3–7 days

1 1.1%

1–4 weeks

3 3.2%

Over a month

7 7.4%

How the animals did

Recovered

33 33%

Still unwell when reported

15 15%

Died

1 1.0%

Euthanised

1 1.0%

Not known

50 50%

Problems reported at the same time

29 29%

28 28%

22 22%

20 20%

7 7.0%

5 5.0%

5 5.0%

4 4.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause stomach upset in dogs?: 100 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with stomach upset