Proteinuria after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 87 reports of proteinuria in dogs after Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

87Reports

76%Marked serious

4.6%Recovered

14%Died or euthanised

21 daysTypical onset

How soon it started

Same day

10 14%

1–2 days

11 16%

3–7 days

8 11%

1–4 weeks

14 20%

Over a month

27 39%

How the animals did

Recovered

4 4.6%

Still unwell when reported

61 70%

Died

3 3.4%

Euthanised

9 10%

Not known

10 11%

Problems reported at the same time

31 36%

27 31%

24 28%

23 26%

22 25%

Didn't work as expected

19 22%

Lethargy

18 21%

Decreased urine concentration

16 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause proteinuria in dogs?: 87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with proteinuria