Hyperglycaemia after Pyrantel + Sarolaner (Simparica Trio) in dogs

90 reports to the FDA describe hyperglycaemia in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

90Reports

86%Marked serious

6.7%Recovered

17%Died or euthanised

2 daysTypical onset

How soon it started

Same day

23 31%

1–2 days

17 23%

3–7 days

11 15%

1–4 weeks

9 12%

Over a month

15 20%

How the animals did

Recovered

6 6.7%

Still unwell when reported

60 67%

Died

6 6.7%

Euthanised

9 10%

Not known

9 10%

Problems reported at the same time

37 41%

32 36%

31 34%

29 32%

24 27%

20 22%

18 20%

16 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause hyperglycaemia in dogs?: 90 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

Hyperglycaemia after Pyrantel 29 reports · 0.6% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with hyperglycaemia