Liver problems after Primidone in dogs

The FDA has received 30 reports of liver problems in dogs after Primidone. That is 24% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports
3.3%Marked serious
0.0%Recovered
10%Died or euthanised
–Typical onset
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How the animals did

Died
3 10%
Not known
27 90%

Problems reported at the same time

Elevated bile acids
10 33%
Lethargy
6 20%
Polyphagia
6 20%
Hypoalbuminaemia
4 13%
Behaviour change
4 13%
Elevated gamma-glutamyl transferase (ggt)
4 13%

Age of the animals

Under 1 year
1
1–3 years
4
4–7 years
14
8–11 years
8
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Primidone cause liver problems in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Primidone in dogs · Medicines most reported with liver problems