Leucopenia after Prednisolone + Trimeprazine in dogs

23 reports to the FDA describe leucopenia in dogs given Prednisolone + Trimeprazine. That is 1.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

30%Marked serious

4.3%Recovered

17%Died or euthanised

20 daysTypical onset

How soon it started

Same day

3 19%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

6 38%

Over a month

7 44%

How the animals did

Recovered

1 4.3%

Still unwell when reported

11 48%

Died

1 4.3%

Euthanised

3 13%

Not known

7 30%

Problems reported at the same time

Neutropenia

10 43%

8 35%

7 30%

7 30%

7 30%

7 30%

6 26%

5 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause leucopenia in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

Leucopenia after Prednisone 123 reports · 1.4% of its reports
Leucopenia after Dexamethasone 62 reports · 2.3% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with leucopenia