Pain after Praziquantel + Pyrantel in dogs

The FDA has received 25 reports of pain in dogs after Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

25Reports

52%Marked serious

16%Recovered

16%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 35%

1–2 days

7 41%

3–7 days

2 12%

1–4 weeks

1 5.9%

Over a month

1 5.9%

How the animals did

Recovered

4 16%

Still unwell when reported

1 4.0%

Died

3 12%

Euthanised

1 4.0%

Not known

16 64%

Problems reported at the same time

10 40%

6 24%

6 24%

4 16%

Inappropriate urination

4 16%

Behaviour change

4 16%

Abdominal pain

3 12%

Breathing problems

3 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause pain in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

Pain after Pyrantel + Sarolaner (Simparica Trio) 148 reports · 0.3% of its reports
Pain after Febantel + Praziquantel + Pyrantel (Drontal Plus) 32 reports · 0.5% of its reports
Pain after Fenbendazole 52 reports · 0.9% of its reports
Pain after Pyrantel 62 reports · 1.3% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with pain