Falling after Praziquantel + Pyrantel in dogs

The FDA has received 22 reports of falling in dogs after Praziquantel + Pyrantel. That is 0.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports

73%Marked serious

18%Recovered

18%Died or euthanised

Same dayTypical onset

How soon it started

Same day

11 55%

1–2 days

5 25%

3–7 days

0 0.0%

1–4 weeks

1 5.0%

Over a month

3 15%

How the animals did

Recovered

4 18%

Died

3 14%

Euthanised

1 4.5%

Not known

14 64%

Problems reported at the same time

9 41%

6 27%

5 23%

5 23%

5 23%

5 23%

4 18%

4 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause falling in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Falling with similar medicines

Falling after Pyrantel + Sarolaner (Simparica Trio) 255 reports · 0.5% of its reports
Falling after Fenbendazole 26 reports · 0.4% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with falling