Proprioception deficit after Phenylpropanolamine (Proin) in dogs

The FDA has received 20 reports of proprioception deficit in dogs after Phenylpropanolamine. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports

85%Marked serious

10%Recovered

20%Died or euthanised

32 daysTypical onset

How soon it started

Same day

2 15%

1–2 days

1 7.7%

3–7 days

2 15%

1–4 weeks

0 0.0%

Over a month

8 62%

How the animals did

Recovered

2 10%

Still unwell when reported

12 60%

Euthanised

4 20%

Not known

2 10%

Problems reported at the same time

8 40%

8 40%

6 30%

4 20%

4 20%

Hind limb paresis

4 20%

Vomiting

3 15%

Knuckling

3 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause proprioception deficit in dogs?: 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 32 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proprioception deficit with similar medicines

Proprioception deficit after Trilostane (Vetoryl) 38 reports · 0.3% of its reports
Proprioception deficit after Levothyroxine 30 reports · 1.0% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with proprioception deficit