Increased heart rate after Phenylpropanolamine (Proin) in dogs

The FDA has received 52 reports of increased heart rate in dogs after Phenylpropanolamine. That is 1.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports

60%Marked serious

63%Recovered

9.6%Died or euthanised

Same dayTypical onset

How soon it started

Same day

24 67%

1–2 days

7 19%

3–7 days

1 2.8%

1–4 weeks

0 0.0%

Over a month

4 11%

How the animals did

Recovered

32 62%

Recovered with lasting effects

1 1.9%

Still unwell when reported

3 5.8%

Died

3 5.8%

Euthanised

2 3.8%

Not known

11 21%

Problems reported at the same time

Breathing problems

24 46%

Restlessness or agitation

15 29%

13 25%

12 23%

11 21%

10 19%

Increased respiratory rate

8 15%

Weakness

7 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause increased heart rate in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with increased heart rate