Dilated pupils after Phenylpropanolamine (Proin) in dogs

59 reports to the FDA describe dilated pupils in dogs given Phenylpropanolamine. That is 1.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

59Reports

63%Marked serious

54%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

40 74%

1–2 days

8 15%

3–7 days

0 0.0%

1–4 weeks

1 1.9%

Over a month

5 9.3%

How the animals did

Recovered

31 53%

Recovered with lasting effects

1 1.7%

Still unwell when reported

7 12%

Not known

20 34%

Problems reported at the same time

Breathing problems

20 34%

Vomiting

17 29%

Restlessness or agitation

16 27%

11 19%

9 15%

9 15%

8 14%

8 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause dilated pupils in dogs?: 59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with dilated pupils