Soft stool after Oclacitinib (Apoquel) in dogs

The FDA has received 44 reports of soft stool in dogs after Oclacitinib. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

44Reports

50%Marked serious

18%Recovered

11%Died or euthanised

8 daysTypical onset

How soon it started

Same day

7 19%

1–2 days

8 22%

3–7 days

3 8.1%

1–4 weeks

3 8.1%

Over a month

16 43%

How the animals did

Recovered

8 18%

Still unwell when reported

22 50%

Died

1 2.3%

Euthanised

4 9.1%

Not known

9 20%

Problems reported at the same time

Vomiting

17 39%

Loss of appetite

12 27%

Lethargy

10 23%

Didn't work as expected

9 20%

7 16%

6 14%

5 11%

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause soft stool in dogs?: 44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Soft stool with similar medicines

Soft stool after Ilunocitinib (Zenrelia) 21 reports · 1.0% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with soft stool