Sleepiness - systemic disorder after Oclacitinib (Apoquel) in dogs

The FDA has received 74 reports of sleepiness - systemic disorder in dogs after Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

74Reports
24%Marked serious
28%Recovered
0.0%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
36 58%
1–2 days
3 4.8%
3–7 days
4 6.5%
1–4 weeks
5 8.1%
Over a month
14 23%

How the animals did

Recovered
20 27%
Recovered with lasting effects
1 1.4%
Still unwell when reported
30 41%
Not known
23 31%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
11
4–7 years
26
8–11 years
15
12+ years
15

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause sleepiness - systemic disorder in dogs?
74 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Sleepiness - systemic disorder with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with sleepiness - systemic disorder