Pyoderma after Oclacitinib (Apoquel) in dogs

218 reports to the FDA describe pyoderma in dogs given Oclacitinib. That is 0.8% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

218Reports

29%Marked serious

7.3%Recovered

6.9%Died or euthanised

74 daysTypical onset

How soon it started

Same day

20 13%

1–2 days

3 1.9%

3–7 days

6 3.9%

1–4 weeks

27 18%

Over a month

98 64%

How the animals did

Recovered

16 7.3%

Still unwell when reported

172 79%

Died

6 2.8%

Euthanised

9 4.1%

Not known

15 6.9%

Problems reported at the same time

Didn't work as expected

108 50%

Skin rash or irritation

42 19%

30 14%

28 13%

25 11%

25 11%

22 10%

21 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause pyoderma in dogs?: 218 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 74 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pyoderma with similar medicines

Pyoderma after Cyclosporine (Atopica) 201 reports · 1.3% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with pyoderma