Elevated lipase after Oclacitinib (Apoquel) in dogs

146 reports to the FDA describe elevated lipase in dogs given Oclacitinib. That is 0.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

146Reports

43%Marked serious

7.5%Recovered

17%Died or euthanised

47 daysTypical onset

How soon it started

Same day

7 7.0%

1–2 days

8 8.0%

3–7 days

7 7.0%

1–4 weeks

14 14%

Over a month

64 64%

How the animals did

Recovered

10 6.8%

Recovered with lasting effects

1 0.7%

Still unwell when reported

100 68%

Died

9 6.2%

Euthanised

16 11%

Not known

10 6.8%

Problems reported at the same time

67 46%

54 37%

53 36%

48 33%

35 24%

31 21%

30 21%

28 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause elevated lipase in dogs?: 146 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 47 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Cyclosporine (Atopica) 88 reports · 0.6% of its reports
Elevated lipase after Ilunocitinib (Zenrelia) 20 reports · 0.9% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with elevated lipase