Elevated lipase after Ilunocitinib (Zenrelia) in dogs

20 reports to the FDA describe elevated lipase in dogs given Ilunocitinib. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports

65%Marked serious

0.0%Recovered

30%Died or euthanised

37 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

4 24%

1–4 weeks

2 12%

Over a month

11 65%

How the animals did

Still unwell when reported

4 20%

Died

1 5.0%

Euthanised

5 25%

Not known

10 50%

Problems reported at the same time

11 55%

9 45%

8 40%

8 40%

Elevated amylase

7 35%

Proteinuria

7 35%

Blood problems

5 25%

Death

5 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause elevated lipase in dogs?: 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 37 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Oclacitinib (Apoquel) 146 reports · 0.5% of its reports
Elevated lipase after Cyclosporine (Atopica) 88 reports · 0.6% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with elevated lipase