Elevated amylase after Oclacitinib (Apoquel) in dogs

The FDA has received 143 reports of elevated amylase in dogs after Oclacitinib. That is 0.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

143Reports

50%Marked serious

4.2%Recovered

17%Died or euthanised

40 daysTypical onset

How soon it started

Same day

7 6.4%

1–2 days

7 6.4%

3–7 days

11 10%

1–4 weeks

25 23%

Over a month

59 54%

How the animals did

Recovered

6 4.2%

Still unwell when reported

99 69%

Died

6 4.2%

Euthanised

18 13%

Not known

14 9.8%

Problems reported at the same time

76 53%

62 43%

54 38%

54 38%

53 37%

38 27%

33 23%

31 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause elevated amylase in dogs?: 143 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 40 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

Elevated amylase after Cyclosporine (Atopica) 91 reports · 0.6% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with elevated amylase