Digestive tract disorder after Oclacitinib (Apoquel) in dogs

The FDA has received 122 reports of digestive tract disorder in dogs after Oclacitinib. That is 0.4% of all reports for this medicine, compared with 2.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

122Reports

43%Marked serious

9.8%Recovered

18%Died or euthanised

42 daysTypical onset

How soon it started

Same day

15 17%

1–2 days

6 6.7%

3–7 days

9 10%

1–4 weeks

14 16%

Over a month

45 51%

How the animals did

Recovered

12 9.8%

Still unwell when reported

68 56%

Died

6 4.9%

Euthanised

16 13%

Not known

20 16%

Problems reported at the same time

33 27%

27 22%

27 22%

25 20%

22 18%

Abnormal ultrasound finding

20 16%

Didn't work as expected

19 16%

Liver problems

13 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause digestive tract disorder in dogs?: 122 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 42 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Digestive tract disorder with similar medicines

Digestive tract disorder after Cyclosporine (Atopica) 135 reports · 0.9% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with digestive tract disorder