Alkaline urine after Oclacitinib (Apoquel) in dogs

The FDA has received 40 reports of alkaline urine in dogs after Oclacitinib. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports

28%Marked serious

15%Recovered

0.0%Died or euthanised

76 daysTypical onset

How soon it started

Same day

2 5.9%

1–2 days

0 0.0%

3–7 days

4 12%

1–4 weeks

6 18%

Over a month

22 65%

How the animals did

Recovered

6 15%

Still unwell when reported

28 70%

Not known

6 15%

Problems reported at the same time

Liver problems

16 40%

Proteinuria

13 33%

Urine abnormalities

12 30%

Decreased urine concentration

11 28%

9 23%

9 23%

7 18%

7 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause alkaline urine in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 76 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Alkaline urine with similar medicines

Alkaline urine after Cyclosporine (Atopica) 21 reports · 0.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with alkaline urine