Liver problems after Metoclopramide in dogs

145 reports to the FDA describe liver problems in dogs given Metoclopramide. That is 25% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

145Reports
84%Marked serious
8.3%Recovered
53%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
13 11%
1–2 days
18 15%
3–7 days
19 16%
1–4 weeks
32 27%
Over a month
38 32%

How the animals did

Recovered
11 7.6%
Recovered with lasting effects
1 0.7%
Still unwell when reported
44 30%
Died
27 19%
Euthanised
50 34%
Not known
12 8.3%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
22
4–7 years
43
8–11 years
47
12+ years
22

About this medicine

Type: medicine.

Questions owners ask

Can Metoclopramide cause liver problems in dogs?
145 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Metoclopramide in dogs · Medicines most reported with liver problems