Lameness after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 62 reports of lameness in dogs after Lufenuron + Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

62Reports

53%Marked serious

23%Recovered

8.1%Died or euthanised

2 daysTypical onset

How soon it started

Same day

4 18%

1–2 days

8 36%

3–7 days

1 4.5%

1–4 weeks

5 23%

Over a month

4 18%

How the animals did

Recovered

12 19%

Recovered with lasting effects

2 3.2%

Still unwell when reported

13 21%

Died

3 4.8%

Euthanised

2 3.2%

Not known

30 48%

Problems reported at the same time

27 44%

14 23%

13 21%

10 16%

9 15%

7 11%

7 11%

6 9.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause lameness in dogs?: 62 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

Lameness after Spinosad (Comfortis) 122 reports · 0.2% of its reports
Lameness after Imidacloprid + Moxidectin (Advantage Multi) 81 reports · 0.6% of its reports
Lameness after Nitenpyram (Capstar) 35 reports · 0.3% of its reports
Lameness after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 23 reports · 0.2% of its reports
Lameness after Fipronil + S-methoprene (Frontline Plus) 22 reports · 0.7% of its reports
Lameness after Flumethrin + Imidacloprid (Seresto) 41 reports · 1.8% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with lameness