Lameness after Fipronil + S-methoprene (Frontline Plus) in dogs
22 reports to the FDA describe lameness in dogs given Fipronil + S-methoprene. That is 0.7% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.
22Reports
45%Marked serious
59%Recovered
0.0%Died or euthanised
160 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause lameness in dogs?
- 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 160 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lameness with similar medicines
- Lameness after Spinosad (Comfortis) 122 reports · 0.2% of its reports
- Lameness after Lufenuron + Milbemycin Oxime (Sentinel) 62 reports · 0.2% of its reports
- Lameness after Imidacloprid + Moxidectin (Advantage Multi) 81 reports · 0.6% of its reports
- Lameness after Nitenpyram (Capstar) 35 reports · 0.3% of its reports
- Lameness after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 23 reports · 0.2% of its reports
- Lameness after Flumethrin + Imidacloprid (Seresto) 41 reports · 1.8% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with lameness