Dehydration after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

47 reports to the FDA describe dehydration in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

47Reports

94%Marked serious

30%Recovered

15%Died or euthanised

1 daysTypical onset

How soon it started

Same day

10 33%

1–2 days

8 27%

3–7 days

3 10%

1–4 weeks

6 20%

Over a month

3 10%

How the animals did

Recovered

14 30%

Still unwell when reported

11 23%

Died

2 4.3%

Euthanised

5 11%

Not known

15 32%

Problems reported at the same time

30 64%

30 64%

26 55%

24 51%

7 15%

7 15%

6 13%

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause dehydration in dogs?: 47 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Spinosad (Comfortis) 281 reports · 0.5% of its reports
Dehydration after Lufenuron + Milbemycin Oxime (Sentinel) 127 reports · 0.5% of its reports
Dehydration after Imidacloprid + Moxidectin (Advantage Multi) 63 reports · 0.5% of its reports
Dehydration after Nitenpyram (Capstar) 42 reports · 0.4% of its reports
Dehydration after Fipronil + S-methoprene (Frontline Plus) 24 reports · 0.8% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with dehydration