Skin rash or irritation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

54 reports to the FDA describe skin rash or irritation in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 1.8% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

54Reports
15%Marked serious
19%Recovered
7.4%Died or euthanised
38 daysTypical onset
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How soon it started

Same day
4 8.7%
1–2 days
8 17%
3–7 days
6 13%
1–4 weeks
5 11%
Over a month
23 50%

How the animals did

Recovered
10 19%
Still unwell when reported
26 48%
Died
1 1.9%
Euthanised
3 5.6%
Not known
14 26%

Problems reported at the same time

Itching
24 44%
Vomiting
15 28%
Diarrhea
14 26%
Loss of appetite
10 19%
Lethargy
9 17%
Skin redness
8 15%
Hair loss
7 13%
Didn't work as expected
7 13%

Age of the animals

Under 1 year
9
1–3 years
13
4–7 years
16
8–11 years
12
12+ years
1

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause skin rash or irritation in dogs?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 38 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with skin rash or irritation