Skin rash or irritation after Lotilaner (Credelio) in dogs

118 reports to the FDA describe skin rash or irritation in dogs given Lotilaner. That is 1.2% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

118Reports

16%Marked serious

10%Recovered

3.4%Died or euthanised

30 daysTypical onset

How soon it started

Same day

23 24%

1–2 days

11 12%

3–7 days

5 5.3%

1–4 weeks

9 9.6%

Over a month

46 49%

How the animals did

Recovered

12 10%

Still unwell when reported

55 47%

Died

1 0.8%

Euthanised

3 2.5%

Not known

47 40%

Problems reported at the same time

50 42%

26 22%

18 15%

16 14%

Didn't work as expected

14 12%

Lethargy

14 12%

Skin redness

14 12%

Reddening of the skin

10 8.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause skin rash or irritation in dogs?: 118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Fluralaner (Bravecto) 661 reports · 1.0% of its reports
Skin rash or irritation after Afoxolaner (NexGard) 958 reports · 1.7% of its reports
Skin rash or irritation after Sarolaner (Simparica) 135 reports · 0.8% of its reports
Skin rash or irritation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 66 reports · 0.7% of its reports
Skin rash or irritation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 54 reports · 1.8% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with skin rash or irritation