Skin redness after Lotilaner (Credelio) in dogs

110 reports to the FDA describe skin redness in dogs given Lotilaner. That is 1.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

110Reports

24%Marked serious

34%Recovered

4.5%Died or euthanised

13 daysTypical onset

How soon it started

Same day

23 27%

1–2 days

11 13%

3–7 days

4 4.7%

1–4 weeks

10 12%

Over a month

37 44%

How the animals did

Recovered

37 34%

Still unwell when reported

39 35%

Died

3 2.7%

Euthanised

2 1.8%

Not known

29 26%

Problems reported at the same time

26 24%

21 19%

20 18%

17 15%

16 15%

Skin rash or irritation

14 13%

Allergic reaction

11 10%

Diarrhea

11 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause skin redness in dogs?: 110 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Fluralaner (Bravecto) 519 reports · 0.8% of its reports
Skin redness after Afoxolaner (NexGard) 1,053 reports · 1.8% of its reports
Skin redness after Sarolaner (Simparica) 119 reports · 0.7% of its reports
Skin redness after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 50 reports · 0.5% of its reports
Skin redness after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 45 reports · 1.5% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with skin redness