Allergic reaction after Lotilaner (Credelio) in dogs

193 reports to the FDA describe allergic reaction in dogs given Lotilaner. That is 1.9% of all reports for this medicine, compared with 2.3% across reports for all dog medicines.

193Reports

39%Marked serious

49%Recovered

4.7%Died or euthanised

2 daysTypical onset

How soon it started

Same day

52 35%

1–2 days

24 16%

3–7 days

10 6.7%

1–4 weeks

12 8.1%

Over a month

51 34%

How the animals did

Recovered

95 49%

Still unwell when reported

47 24%

Died

9 4.7%

Not known

42 22%

Problems reported at the same time

68 35%

67 35%

44 23%

40 21%

25 13%

23 12%

20 10%

18 9.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause allergic reaction in dogs?: 193 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

Allergic reaction after Fluralaner (Bravecto) 1,116 reports · 1.6% of its reports
Allergic reaction after Afoxolaner (NexGard) 986 reports · 1.7% of its reports
Allergic reaction after Sarolaner (Simparica) 318 reports · 1.9% of its reports
Allergic reaction after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 140 reports · 1.5% of its reports
Allergic reaction after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 56 reports · 1.8% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with allergic reaction