Pale mucous membrane after Lotilaner (Credelio) in dogs

The FDA has received 65 reports of pale mucous membrane in dogs after Lotilaner. That is 0.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

65Reports

85%Marked serious

45%Recovered

20%Died or euthanised

35 daysTypical onset

How soon it started

Same day

12 28%

1–2 days

5 12%

3–7 days

0 0.0%

1–4 weeks

4 9.3%

Over a month

22 51%

How the animals did

Recovered

29 45%

Still unwell when reported

15 23%

Died

4 6.2%

Euthanised

9 14%

Not known

8 12%

Problems reported at the same time

32 49%

25 38%

20 31%

16 25%

16 25%

14 22%

13 20%

13 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause pale mucous membrane in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Fluralaner (Bravecto) 267 reports · 0.4% of its reports
Pale mucous membrane after Afoxolaner (NexGard) 225 reports · 0.4% of its reports
Pale mucous membrane after Sarolaner (Simparica) 66 reports · 0.4% of its reports
Pale mucous membrane after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports
Pale mucous membrane after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 22 reports · 0.7% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with pale mucous membrane