Pale mucous membrane after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

22 reports to the FDA describe pale mucous membrane in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 0.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

22Reports

73%Marked serious

27%Recovered

27%Died or euthanised

98 daysTypical onset

How soon it started

Same day

4 20%

1–2 days

2 10%

3–7 days

0 0.0%

1–4 weeks

4 20%

Over a month

10 50%

How the animals did

Recovered

6 27%

Still unwell when reported

6 27%

Died

4 18%

Euthanised

2 9.1%

Not known

4 18%

Problems reported at the same time

16 73%

11 50%

10 45%

7 32%

6 27%

6 27%

6 27%

5 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause pale mucous membrane in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 98 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Fluralaner (Bravecto) 267 reports · 0.4% of its reports
Pale mucous membrane after Afoxolaner (NexGard) 225 reports · 0.4% of its reports
Pale mucous membrane after Sarolaner (Simparica) 66 reports · 0.4% of its reports
Pale mucous membrane after Lotilaner (Credelio) 65 reports · 0.7% of its reports
Pale mucous membrane after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with pale mucous membrane