Pale mucous membrane after Fluralaner (Bravecto) in dogs

The FDA has received 267 reports of pale mucous membrane in dogs after Fluralaner. That is 0.4% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

267Reports

97%Marked serious

22%Recovered

43%Died or euthanised

1 daysTypical onset

How soon it started

Same day

80 42%

1–2 days

39 20%

3–7 days

17 8.9%

1–4 weeks

22 11%

Over a month

34 18%

How the animals did

Recovered

57 21%

Recovered with lasting effects

2 0.7%

Still unwell when reported

71 27%

Died

46 17%

Euthanised

68 25%

Not known

23 8.6%

Problems reported at the same time

143 54%

125 47%

114 43%

102 38%

82 31%

81 30%

79 30%

73 27%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause pale mucous membrane in dogs?: 267 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Afoxolaner (NexGard) 225 reports · 0.4% of its reports
Pale mucous membrane after Sarolaner (Simparica) 66 reports · 0.4% of its reports
Pale mucous membrane after Lotilaner (Credelio) 65 reports · 0.7% of its reports
Pale mucous membrane after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports
Pale mucous membrane after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 22 reports · 0.7% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with pale mucous membrane