Blood problems after Fluralaner (Bravecto) in dogs

634 reports to the FDA describe blood problems in dogs given Fluralaner. That is 0.9% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

634Reports

96%Marked serious

9.9%Recovered

38%Died or euthanised

7 daysTypical onset

How soon it started

Same day

67 17%

1–2 days

86 22%

3–7 days

51 13%

1–4 weeks

60 15%

Over a month

131 33%

How the animals did

Recovered

52 8.2%

Recovered with lasting effects

11 1.7%

Still unwell when reported

266 42%

Died

71 11%

Euthanised

172 27%

Not known

62 9.8%

Problems reported at the same time

319 50%

311 49%

243 38%

243 38%

189 30%

Decreased packed cell volume (pcv)

133 21%

Kidney problems

129 20%

Leucocytosis

124 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

200

8–11 years

210

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause blood problems in dogs?: 634 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Afoxolaner (NexGard) 544 reports · 1.0% of its reports
Blood problems after Sarolaner (Simparica) 159 reports · 1.0% of its reports
Blood problems after Lotilaner (Credelio) 125 reports · 1.3% of its reports
Blood problems after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 59 reports · 0.6% of its reports
Blood problems after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 37 reports · 1.2% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with blood problems