Blood problems after Lotilaner (Credelio) in dogs

125 reports to the FDA describe blood problems in dogs given Lotilaner. That is 1.3% of all reports for this medicine, compared with 1.8% across reports for all dog medicines.

125Reports

78%Marked serious

7.2%Recovered

23%Died or euthanised

33 daysTypical onset

How soon it started

Same day

11 13%

1–2 days

10 11%

3–7 days

9 10%

1–4 weeks

11 13%

Over a month

47 53%

How the animals did

Recovered

9 7.2%

Still unwell when reported

51 41%

Died

10 8.0%

Euthanised

19 15%

Not known

36 29%

Problems reported at the same time

62 50%

54 43%

33 26%

30 24%

29 23%

25 20%

Didn't work as expected

23 18%

Fever

22 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause blood problems in dogs?: 125 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 33 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Fluralaner (Bravecto) 634 reports · 0.9% of its reports
Blood problems after Afoxolaner (NexGard) 544 reports · 1.0% of its reports
Blood problems after Sarolaner (Simparica) 159 reports · 1.0% of its reports
Blood problems after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 59 reports · 0.6% of its reports
Blood problems after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 37 reports · 1.2% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with blood problems