Liver problems after Lotilaner (Credelio) in dogs

The FDA has received 220 reports of liver problems in dogs after Lotilaner. That is 2.2% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

220Reports

56%Marked serious

8.2%Recovered

15%Died or euthanised

42 daysTypical onset

How soon it started

Same day

22 14%

1–2 days

24 15%

3–7 days

13 8.2%

1–4 weeks

13 8.2%

Over a month

87 55%

How the animals did

Recovered

18 8.2%

Still unwell when reported

81 37%

Died

14 6.4%

Euthanised

18 8.2%

Not known

89 40%

Problems reported at the same time

74 34%

69 31%

65 30%

52 24%

40 18%

35 16%

33 15%

32 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause liver problems in dogs?: 220 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 42 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Fluralaner (Bravecto) 1,685 reports · 2.5% of its reports
Liver problems after Afoxolaner (NexGard) 1,408 reports · 2.5% of its reports
Liver problems after Sarolaner (Simparica) 397 reports · 2.4% of its reports
Liver problems after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 172 reports · 1.9% of its reports
Liver problems after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 76 reports · 2.5% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with liver problems