Kidney problems after Lotilaner (Credelio) in dogs

144 reports to the FDA describe kidney problems in dogs given Lotilaner. That is 1.4% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

144Reports

62%Marked serious

6.3%Recovered

21%Died or euthanised

36 daysTypical onset

How soon it started

Same day

15 15%

1–2 days

15 15%

3–7 days

7 7.1%

1–4 weeks

8 8.2%

Over a month

53 54%

How the animals did

Recovered

9 6.3%

Still unwell when reported

60 42%

Died

13 9.0%

Euthanised

17 12%

Not known

45 31%

Problems reported at the same time

66 46%

53 37%

52 36%

44 31%

33 23%

30 21%

23 16%

Elevated symmetrical dimethylarginine (sdma)

21 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause kidney problems in dogs?: 144 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 36 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Fluralaner (Bravecto) 896 reports · 1.3% of its reports
Kidney problems after Afoxolaner (NexGard) 663 reports · 1.2% of its reports
Kidney problems after Sarolaner (Simparica) 209 reports · 1.3% of its reports
Kidney problems after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 84 reports · 0.9% of its reports
Kidney problems after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 34 reports · 1.1% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with kidney problems