Kidney problems after Sarolaner (Simparica) in dogs

The FDA has received 209 reports of kidney problems in dogs after Sarolaner. That is 1.3% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

209Reports

74%Marked serious

7.7%Recovered

27%Died or euthanised

1 daysTypical onset

How soon it started

Same day

65 37%

1–2 days

40 23%

3–7 days

22 13%

1–4 weeks

17 9.8%

Over a month

30 17%

How the animals did

Recovered

16 7.7%

Still unwell when reported

117 56%

Died

12 5.7%

Euthanised

44 21%

Not known

20 9.6%

Problems reported at the same time

83 40%

70 33%

68 33%

55 26%

53 25%

51 24%

45 22%

43 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause kidney problems in dogs?: 209 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Fluralaner (Bravecto) 896 reports · 1.3% of its reports
Kidney problems after Afoxolaner (NexGard) 663 reports · 1.2% of its reports
Kidney problems after Lotilaner (Credelio) 144 reports · 1.4% of its reports
Kidney problems after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 84 reports · 0.9% of its reports
Kidney problems after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 34 reports · 1.1% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with kidney problems