Skin rash or irritation after Sarolaner (Simparica) in dogs

135 reports to the FDA describe skin rash or irritation in dogs given Sarolaner. That is 0.8% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

135Reports

39%Marked serious

12%Recovered

3.7%Died or euthanised

2 daysTypical onset

How soon it started

Same day

30 25%

1–2 days

31 26%

3–7 days

10 8.5%

1–4 weeks

22 19%

Over a month

25 21%

How the animals did

Recovered

16 12%

Still unwell when reported

72 53%

Died

1 0.7%

Euthanised

4 3.0%

Not known

42 31%

Problems reported at the same time

44 33%

20 15%

19 14%

16 12%

16 12%

15 11%

14 10%

13 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause skin rash or irritation in dogs?: 135 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Fluralaner (Bravecto) 661 reports · 1.0% of its reports
Skin rash or irritation after Afoxolaner (NexGard) 958 reports · 1.7% of its reports
Skin rash or irritation after Lotilaner (Credelio) 118 reports · 1.2% of its reports
Skin rash or irritation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 66 reports · 0.7% of its reports
Skin rash or irritation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 54 reports · 1.8% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with skin rash or irritation