Skin rash or irritation after Fluralaner (Bravecto) in dogs

661 reports to the FDA describe skin rash or irritation in dogs given Fluralaner. That is 1.0% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

661Reports

80%Marked serious

16%Recovered

5.4%Died or euthanised

5 daysTypical onset

How soon it started

Same day

82 19%

1–2 days

92 22%

3–7 days

67 16%

1–4 weeks

61 14%

Over a month

121 29%

How the animals did

Recovered

94 14%

Recovered with lasting effects

9 1.4%

Still unwell when reported

411 62%

Died

15 2.3%

Euthanised

21 3.2%

Not known

111 17%

Problems reported at the same time

249 38%

117 18%

108 16%

85 13%

78 12%

75 11%

73 11%

72 11%

Age of the animals

Under 1 year

1–3 years

167

4–7 years

216

8–11 years

142

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause skin rash or irritation in dogs?: 661 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

Skin rash or irritation after Afoxolaner (NexGard) 958 reports · 1.7% of its reports
Skin rash or irritation after Sarolaner (Simparica) 135 reports · 0.8% of its reports
Skin rash or irritation after Lotilaner (Credelio) 118 reports · 1.2% of its reports
Skin rash or irritation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 66 reports · 0.7% of its reports
Skin rash or irritation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 54 reports · 1.8% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with skin rash or irritation