Hair loss after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

The FDA has received 48 reports of hair loss in dogs after Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 1.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports

10%Marked serious

10%Recovered

2.1%Died or euthanised

29 daysTypical onset

How soon it started

Same day

5 11%

1–2 days

7 15%

3–7 days

6 13%

1–4 weeks

6 13%

Over a month

23 49%

How the animals did

Recovered

5 10%

Still unwell when reported

27 56%

Euthanised

1 2.1%

Not known

15 31%

Problems reported at the same time

Itching

20 42%

Skin rash or irritation

7 15%

Skin redness

7 15%

Reddening of the skin

5 10%

5 10%

4 8.3%

4 8.3%

4 8.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause hair loss in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 29 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

Hair loss after Fluralaner (Bravecto) 776 reports · 1.1% of its reports
Hair loss after Afoxolaner (NexGard) 844 reports · 1.5% of its reports
Hair loss after Sarolaner (Simparica) 132 reports · 0.8% of its reports
Hair loss after Lotilaner (Credelio) 102 reports · 1.0% of its reports
Hair loss after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 70 reports · 0.8% of its reports

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with hair loss