Excessive thirst after Lokivetmab (Cytopoint) in dogs

The FDA has received 234 reports of excessive thirst in dogs after Lokivetmab. That is 3.6% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

234Reports

45%Marked serious

6.8%Recovered

6.0%Died or euthanised

9 daysTypical onset

How soon it started

Same day

35 20%

1–2 days

25 15%

3–7 days

22 13%

1–4 weeks

27 16%

Over a month

63 37%

How the animals did

Recovered

14 6.0%

Recovered with lasting effects

2 0.9%

Still unwell when reported

171 73%

Died

3 1.3%

Euthanised

11 4.7%

Not known

33 14%

Problems reported at the same time

161 69%

50 21%

48 21%

45 19%

Didn't work as expected

43 18%

Vomiting

41 18%

Decreased urine concentration

39 17%

Kidney problems

30 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause excessive thirst in dogs?: 234 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

Excessive thirst after Bedinvetmab (Librela) 1,877 reports · 9.6% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with excessive thirst