Liver problems after Lokivetmab (Cytopoint) in dogs

559 reports to the FDA describe liver problems in dogs given Lokivetmab. That is 8.6% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

559Reports

62%Marked serious

5.7%Recovered

17%Died or euthanised

20 daysTypical onset

How soon it started

Same day

77 19%

1–2 days

45 11%

3–7 days

41 10%

1–4 weeks

74 18%

Over a month

171 42%

How the animals did

Recovered

31 5.5%

Recovered with lasting effects

1 0.2%

Still unwell when reported

352 63%

Died

28 5.0%

Euthanised

68 12%

Not known

79 14%

Problems reported at the same time

Loss of appetite

202 36%

Vomiting

197 35%

Lethargy

184 33%

Didn't work as expected

120 21%

114 20%

96 17%

93 17%

84 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

147

8–11 years

229

12+ years

118

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause liver problems in dogs?: 559 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Bedinvetmab (Librela) 1,579 reports · 8.0% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with liver problems