Decreased urine concentration after Lokivetmab (Cytopoint) in dogs

68 reports to the FDA describe decreased urine concentration in dogs given Lokivetmab. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

68Reports

47%Marked serious

1.5%Recovered

13%Died or euthanised

25 daysTypical onset

How soon it started

Same day

7 15%

1–2 days

4 8.5%

3–7 days

6 13%

1–4 weeks

10 21%

Over a month

20 43%

How the animals did

Recovered

1 1.5%

Still unwell when reported

48 71%

Died

4 5.9%

Euthanised

5 7.4%

Not known

10 15%

Problems reported at the same time

39 57%

34 50%

26 38%

22 32%

17 25%

Didn't work as expected

17 25%

Proteinuria

16 24%

Vomiting

13 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause decreased urine concentration in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 25 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

Decreased urine concentration after Bedinvetmab (Librela) 361 reports · 1.8% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with decreased urine concentration