Unresponsive after Leptospirosis Vaccine in dogs

The FDA has received 68 reports of unresponsive in dogs after Leptospirosis Vaccine. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

68Reports

93%Marked serious

22%Recovered

41%Died or euthanised

Same dayTypical onset

How soon it started

Same day

31 51%

1–2 days

6 9.8%

3–7 days

4 6.6%

1–4 weeks

6 9.8%

Over a month

14 23%

How the animals did

Recovered

14 21%

Recovered with lasting effects

1 1.5%

Still unwell when reported

21 31%

Died

17 25%

Euthanised

11 16%

Not known

4 5.9%

Problems reported at the same time

28 41%

27 40%

24 35%

23 34%

21 31%

19 28%

17 25%

15 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause unresponsive in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

Unresponsive after Rabies Vaccine 107 reports · 1.1% of its reports
Unresponsive after Bordetella Vaccine 77 reports · 0.8% of its reports
Unresponsive after Distemper-parvo Vaccine 70 reports · 1.1% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with unresponsive