Increased packed cell volume (pcv) after Leptospirosis Vaccine in dogs

The FDA has received 33 reports of increased packed cell volume (pcv) in dogs after Leptospirosis Vaccine. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports

79%Marked serious

21%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

14 48%

1–2 days

4 14%

3–7 days

0 0.0%

1–4 weeks

4 14%

Over a month

7 24%

How the animals did

Recovered

7 21%

Still unwell when reported

18 55%

Euthanised

4 12%

Not known

4 12%

Problems reported at the same time

26 79%

19 58%

14 42%

13 39%

10 30%

9 27%

Didn't work as expected

8 24%

Dehydration

7 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause increased packed cell volume (pcv) in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Increased packed cell volume (pcv) with similar medicines

Increased packed cell volume (pcv) after Rabies Vaccine 43 reports · 0.4% of its reports
Increased packed cell volume (pcv) after Bordetella Vaccine 34 reports · 0.4% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with increased packed cell volume (pcv)