Enlarged liver after Leptospirosis Vaccine in dogs

25 reports to the FDA describe enlarged liver in dogs given Leptospirosis Vaccine. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

25Reports

88%Marked serious

0.0%Recovered

32%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 38%

1–2 days

3 19%

3–7 days

2 13%

1–4 weeks

3 19%

Over a month

2 13%

How the animals did

Still unwell when reported

13 52%

Died

2 8.0%

Euthanised

6 24%

Not known

4 16%

Problems reported at the same time

18 72%

15 60%

15 60%

14 56%

14 56%

Abnormal radiograph finding

10 40%

Blood problems

9 36%

Death

9 36%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause enlarged liver in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Enlarged liver with similar medicines

Enlarged liver after Rabies Vaccine 21 reports · 0.2% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with enlarged liver